Alaabta
2,4-Diamino-6-hydroxypyrimidine
Guryaha Kiimikada Hydroxypyrimidine
| barta dhalaalaysa | 285-286 °C (dec.) (Iftiin) |
| Barta karkarinta | 234.22°C (qiyaasta qallafsan) |
| cufnaanta | 1.3659 (Qiyaas adag) |
| index refractive | 1.7990 (qiyaas) |
| heerkulka kaydinta. | Ku hay meel mugdi ah, jawi aan fiicneyn, heerkulka qolka |
| milmayn | DMSO (wax yar), Methanol (wax yar) |
| pka | 10.61±0.50 (La saadaaliyay) |
| qaab | Budada Crystalline Fine |
| midab | Cadaan ilaa kareem |
| Xasaasi ah | Iftiinka xasaasiga ah |
| Merck | 14,2981 |
| BRN | 125006 |
| InChiKey | SWELIMKTDYHAOY-UHFFFAOYSA-N |
| Tixraaca XogtaBase ee CAS | 56-06-4 (Tixraaca Xogta Saldhigga CAS) |
| Tixraaca Kiimikada NIST | 4 (1H)-pyrimidinone, 2,6-diamino-(56-06-4) |
| Nidaamka Diiwaanka Walxaha EPA | 2,6-Diamino-4(1H)-pyrimidinone (56-06-4) |
Sharaxaada Alaabta Hydroxypyrimidine
2,4-Diamino-6-hydroxypyrimidine waa iskudhis kiimiko ah oo leh caanaha molecular C4H6N4O.Waa iskudhis organic ah oo ka tirsan qoyska pyrimidine.Xaruntu waxay leedahay qaab dhismeedka giraanta pyrimidine, laba kooxood oo amino ah (NH2) waxay ku xiran yihiin booska 2 iyo 4, kooxda hydroxyl (OH) waxay ku xiran tahay booska 6.Qaab dhismeedka kiimikada waxa lagu tilmaami karaa sida:Ammonia ||H--C--C--C--N--C--C--NH2 ||oh 2,4-Diamino-6-hydroxypyrimidine waxay leedahay codsiyo kala duwan warshadaha dawooyinka.Waa dhexdhexaad muhiim ah oo ka mid ah isku-darka dawooyin badan, oo ay ku jiraan daawooyinka fayraska iyo antitumor.Waxa kale oo loo isticmaalaa in lagu soo saaro dhowr analoog oo nucleotide ah oo loo isticmaalo cilmi-baarista dawooyinka.
Marka laga soo tago codsiyada dawooyinka, 2,4-diamino-6-hydroxypyrimidine ayaa sidoo kale loo isticmaalaa sida qayb ka mid ah agrochemicals.Waa qayb muhiim ah oo ka mid ah isku-darka nidaamiyeyaasha koritaanka dhirta iyo fungicides.Aad bay muhiim u tahay in la raaco nidaamka badbaadada saxda ah marka la isticmaalayo 2,4-diamino-6-hydroxypyrimidine.Maadaama lagu sifeeyay inay tahay cuncun kiimiko ah, waa in si taxadar leh loo qabtaa oo waa in la xidho qalab ku filan oo ilaalin shakhsi ah si looga fogaado xiriir toos ah.
Marka la soo koobo, 2,4-diamino-6-hydroxypyrimidine waa iskudhis organic ah oo leh codsiyo ku saabsan beeraha farmashiyaha iyo beeraha.Qaab dhismeedkeeda kiimikaad ayaa ka dhigaysa mid faa'iido u leh sida dhexdhexaadka ah ee isku dhafka daawooyinka iyo xakamaynta koritaanka dhirta.
Macluumaadka Badbaadada
| Xeerarka halista | Xi |
| Bayaanka Khatarta | 36/37/38 |
| Bayaanada Badbaadada | 22-24/25-36-26 |
| WGK Germany | 3 |
| Xusuusin Khatarta | Xanaaqsan |
| TSCA | Haa |
| Koodhka HS | 29335995 |
Isticmaalka Hydroxypyrimidine iyo Synthesis
| Sharaxaada | 2,4-Diamino-6-hydroxypyrimidine (DAHP) waa xakameyn gaar ah oo xakameynaya GTP cyclohydrolase I, heerka xaddidaadda qiyaasta de novo pterin synthesis.Unugyada HUVEC, IC50si looga hortago BH4biosynthesis waa qiyaastii 0.3 mM.DAHP waxaa loo isticmaali karaa in si wax ku ool ah loo joojiyo wax soo saarka NO ee dhowr nooc oo unug ah. |
| Guryaha Kiimikada | Caddaan Adag |
| Adeegsada | 2,4-Diamino-6-hydroxypyrimidine (DAHP) waa xakameyn gaar ah oo xakameynaya GTP cyclohydrolase I, heerka xaddidaadda qiyaasta de novo pterin synthesis.Unugyada HUVEC, IC50 ee ka hortagga biosynthesis ee BH4 waxay ku saabsan tahay 0.3 mM.DAHP waxa loo isticmaali karaa in si wax ku ool ah loo joojiyo wax soo saarka NO ee noocyo kala duwan oo unug ah.[Cayman Chemical] |
| Adeegsada | Waxay taagan tahay bilawga cascade-catalyzed enzyme ee ka bilaabma karbohaydraytkan todoba-kaarbon ah waxayna ku dhammaataa asiidhyada amino ee phenylalanine, tyrosine, iyo tryptophan |
| Adeegsada | 2,4-Diamino-6-hydroxypyrimidine (cas # 56-06-4) waa iskudhis faa'iido u leh isku-dhafka dabiiciga ah. |
| Hababka Sifaynta | Waxay dib uga soo noqotaa H2O.[Beilstein 25 III/IV 3642.] |
