| Guryaha Kiimikada | Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) waa kiristaalo aan midab lahayn ama caddaan ama huruud ah, tiro adag ama dareere saafi ah.Waxay ku dhalaalisaa heerkulka qolka (mp=23°C).Kuma dabar go'o markan ama xitaa heerkulka sare sare.Tusaale ahaan, waxaa sida caadiga ah lagu nadiifiyaa distillation iyadoo hoos loo dhigo cadaadiska hoos u dhaca heerkulka ilaa 65 ° C.Heerkulka sare wuxuu u kala go'i doonaa isobutene, alkohol t-butyl iyo carbon dioxide. |
| Adeegsada | Di-tert-butyl dikarbonate (Boc2O) waa reagent aad loo isticmaalo si loogu soo bandhigo kooxaha ilaalinta ee isku-dhafka peptide.Waxay ka ciyaartaa door muhiim ah diyaarinta 6-acetyl-1,2,3,4-tetrahydropyridine iyadoo la fal-celinaysa 2-piperidone.Waxay u adeegtaa sidii koox ilaalin ah oo loo isticmaalo isku-dhafka peptide wejiga adag. |
| Diyaarinta | Diyaarinta Di-tert-butyl dikarbonate waa sida soo socota: Si a monoester xal cusbo sodium lagu daray 2g N, N-dimethylformamide, 1g of pyridine, 1g of triethylamine, Qaboojin ilaa -5 ~ 0 ° C, 60g diphosgene si tartiib tartiib ah lagu daray hoos u dhac ku yimid 1.5h ku darida hoos u dhaca ayaa la dhameeyay, waxaa lagu diiray heerkulka qolka (25°C), oo lagu beeray 2h, falcelinta ayaa loo oggolaaday inay istaagto shaandhaynta ka dib, maydhista xal organic.Qalalan leh magnesium sulfate oo anhydrous ah, dareeraha ayaa laga saaray cadaadiska atmospheric si loo siiyo badeecada cayriin 65 ~ 70g.Ka dib qaboojinta iyo crystallization, 57-60g of di-tert-butyl dicarbonate ayaa la helay wax-soo-saarka 60-63%. |
| Qeexid | ChEBI: Di-tert-butyl dikarbonateed waa anhydride karboksilic acyclic ah.Waxay si firfircoon ula xiriirtaa dicarbonic acid. |
| Falcelinta | Dareen-celinta anilines ee lagu beddelay Boc2O iyadoo ay jirto qadar stoichiometric ah 4-dimethylaminopyridine (DMAP) ee dareeraha aan firfircoonayn (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) heerkulka qolka wuxuu keenaa aryl isocyyanates in ku dhawaad halbeeg min.
Di-tert-butyl dicarbonate iyo 4- (dimethylamino) pyridine ayaa dib loo booqday.Falcelintooda amines iyo aalkolada |
| Sharaxaada Guud | Di-tert-butyl dicarbonate (Boc2O) waa reagent inta badan loo isticmaalo soo bandhigida kooxda ilaalinta Boc si loo aamino hawlaha.Waxa kale oo loo isticmaalaa sida wakiilka fuuq-baxa ee fal-celinta dabiiciga ah, gaar ahaan asiidhyada karboxilic, kooxaha hydroxyl qaarkood, ama nitroalkanes aasaasiga ah. |
| Hazard | Cuncun sababi kara dhaawac isha oo halis ah;Waxay keeni kartaa dareenka maqaarka;Aad u sun ah neefsashada |
| Daboolida iyo Qarxinta | guban kara |
| Hababka Sifaynta | Ku dhalaali ester-ka adiga oo ku kululeynaya ~35o, oo ku kala dir meel faaruq ah.Haddii IR iyo NMR (1810m 1765 cm-1, in CCl4 1.50 singlet) ay soo jeediyaan nadiif aad u sarreeya, ka dibna ku dhaq mug siman oo H2O ah oo ay ku jirto citric acid si lakabka aqueous ka dhigo mid acidic ah, soo ururi lakabka organic oo ku qalaji MgSO4. oo ku kala saar meel bannaan.[Pope et al.Org Synth 57 45 1977, Keller iyo al.Org Synth 63 160 1985, Grehn iyo al.Angew Chem 97 519 1985.] OLOL. |
