N-Methyl-2-pyrrolidone

Sharaxaad Gaaban:

Magaca Alaabta:N-Methyl-2-pyrrolidone

La mid ah:M-PYROL (R); 1-Methyl-2-pyrrolidinone (99.5%, HyDry, Water≤50 ppm (by KF)) ppm (waxaa qoray KF)); Soo saaraha N-Methyl-2-pyrrolidone;1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE ACS); 1-Methyl-2-pyrrolidinone 872-50-4 NMP N-Methyl-2-pyrrolidinone; N-Methyl-2-pyrrolidinone 872-50-4 NMP; 1-METHYL-2-PYRROLIDINONE

CAS:872-50-4

MF:C5H9NO

MW:99.13

EINECS:212-828-1

Qaybaha Alaabta:NMP; Qalabka ceeriin ee kiimikaad ah ICP-MS; Sunta (marka laga reebo sunta cayayaanka/haraaga dawooyinka); Codsiyada; Falanqaynta Cabbitaannada; Dhismooyinka; C4 ilaa C8; Isku-dhafka Kiimikada; Cunto & Reagents for Inorganic Race Analysis, Xalalka Falanqaynta Speciation Birta, Xalalka Falanqaynta Gaarka ah (LC-ICP-MS) Codsiga; Tamarta Beddelka ah, Dhalooyinka Dhalooyinka Amber, Reagents Analytical; Analytical/Chromatography;CHROMASOLV Plus;Chromatography Reagents &;Electrolytes;HPLC &;HPLC Plus Fasalka Xalalka (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV); Xalalka dabiiciga ah, Kala-Darka-Bulk, Dhalooyinka Kala-baxa, Ikhtiyaarada Baakadaha Xalka; UHPLC Xalalka (CHROMASOLV); NMR Hubi/Shaabad?Dhalooyinka;872-50-4;bc0001

Mol File:872-50-4.mol

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Faahfaahinta Alaabta

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Guryaha Kiimikada ee Pyrrolidone

barta dhalaalaysa	-24 °C (iftiin)
Barta karkarinta	202 °C ( shid) 81-82 °C/10 mmHg ( shidday)
cufnaanta	1.028 g/ml at 25 °C (iftiin)
cufnaanta uumiga	3.4 ( vs hawada)
cadaadiska uumiga	0.29 mm Hg (20 °C)
index refractive	n20/D 1.479
Fp	187 °F
heerkulka kaydinta.	Ku kaydi heerkulka +5°C ilaa +30°C.
milmayn	ethanol: miscible0.1ML/ml, cad, aan midab lahayn (10%, v/v)
qaab	Dareeraha
pka	-0.41±0.20 (La saadaaliyay)
midab	≤20 (APHA)
PH	8.5-10.0 (100g/l, H2O, 20℃)
ur	Amin udgoon yar
Xaddiga PH	7.7 - 8.0
xadka qarxa	1.3-9.5% (V)
Biyuhu milmayn	= 10 g/100 ml oo ah 20ºC
Xasaasi ah	Hygroscopic
ugu badnaan	283nm (MeOH) ( shidan)
Merck	14,6117
BRN	106420
Xasilooni	Deggan, laakiin wuu qudhma marka uu iftiimo.guban karaAan ku habboonayn walxaha oksaydhiyeyaasha xooggan, acids xooggan, wakiilada yaraynta, saldhigyada.
InChiKey	SECXISVLQFMRJM-UHFFFAOYSA-N
LogP	-0.46 at 25 ℃
Tixraaca XogtaBase ee CAS	872-50-4 (Tixraaca Xogta Saldhigga CAS)
Tixraaca Kiimikada NIST	2-Pyrrolidinone, 1-methyl-(872-50-4)
Nidaamka Diiwaanka Walxaha EPA	N-Methyl-2-pyrrolidone (872-50-4)

Macluumaadka Badbaadada

Xeerarka halista	T, Xi
Bayaanka Khatarta	45-65-36/38-36/37/38-61-10-46
Bayaanada Badbaadada	41-45-53-62-26
WGK Germany	1
RTECS	UY5790000
F	3-8-10
Heerkulka iswada	518 °F
TSCA	Y
Koodhka HS	2933199090
Xogta Walxaha halista ah	872-50-4(Xogta Walxaha halista ah)
Sunta	LD50 afka ah ee Bakaylaha: 3598 mg/kg LD50 dermal Bakayle 8000 mg/kg

Isticmaalka Pyrrolidone iyo Synthesis

Guryaha Kiimikada	N-Methyl-2-pyrrolidone waa dareere hufan oo huruud ah oo aan midab lahayn ama iftiin leh oo leh ur ammonia yar.N-Methyl-2-pyrrolidone gabi ahaanba waa lagu qallajin karaa biyo.Aad bay ugu milmi kartaa aalkolada hoose, ketones hoose, ether, ethyl acetate, chloroform, iyo benzene waxayna si dhexdhexaad ah ugu milmaan hydrocarbons aliphatic.N-Methyl-2-pyrrolidone waa hygroscopic xoog leh, kiimiko ahaan deggan, aan daxalaynin xagga birta kaarboonka iyo aluminiumka, oo waxoogaa daxalaysa ilaa naxaas.Waxay leedahay xabag hoose, kiimiko xooggan iyo degganaansho kulayl, polarity sare, iyo isbeddel hooseeya.Alaabtani xoogaa sun ah, xadkeeda la oggolaaday ee hawodu waa 100ppm. N-Methyl-2-pyrrolidone waa dareere loo isticmaalo warshado iyo codsiyo kala duwan, sida rinjiga iyo saarista dahaadhka, farsamaynta batroolka, dahaarka caagagga injineernimada, kiimikooyinka beeraha, nadiifinta elektiroonigga ah iyo nadiifinta warshadaha/guriga.
Adeegsada	N-Methyl-2-pyrrolidone (NMP) waa dareere aprotic polar ah kaas oo leh faa'iidooyinka sunta hoose, barta karkarinta sare, xalinta heer sare ah, xulashada xooggan iyo xasilloonida wanaagsan.Waxaa si weyn loo isticmaalaa sifaynta soo saarista hydrocarbon udgoon, acetylene, olefins, iyo diolefins. Waxaa loo isticmaalaa nadiifinta warshadaha, waxayna u adeegtaa sidii dareere loogu talagalay soo saarista sunta cayayaanka, balaastikada injineernimada, dahaarka, fiilooyinka synthetic, iyo wareegyada isku dhafan. Waxa kale oo loo isticmaali karaa nadiifiyaha warshadaha, kala-firdhiye, dheeha, saliidaha iyo barafka ka-hortagga. N-Methyl-2-pyrrolidone waa dareere aad u fiican, oo si ballaaran loo isticmaalo soo saarista aromatics, sifaynta saliidda, kobcinta acetylene, kala-soocidda butadiene iyo desulfurization gaaska synthesis. Waxaa loo isticmaalaa in desulfurization gaaska, saliid sifaynta saliidda, saliid antifreeze saliid saliid, soo saaridda olefin, iyo sida dareere loogu talagalay balaastikada injineernimada ee aan milmin polymerization. Waxaa loo isticmaali karaa in lagu nadiifiyo maaddooyinka dahaarka, qalabyada saxan warshadaha semiconductor iyo looxyada wareegga, dib u warshadaynta qiiqa PVC, sida saabuunta, dheeha kabka iyo wakiilka kala firdhiso. Waxaa loo isticmaalaa dhexdhexaadinta falcelinta polymerization sida balaastikada injineernimada iyo fiber aramid. N-Methyl-2-pyrrolidone waxaa loo isticmaalaa sida dareeraha fluoride polyvinylidene iyo walxo kaaliyaha korantada ee baytariyada lithium ion. darajada nadiifnimada sare ee ogaanshaha ICP-MS. Si loo abuuro peptide.
sunta	Afka (mus) LD50:5130 mg/kg;Oral (jiir) LD50:3914 mg/kg;Dermal (rbt) LD50:8000 mg/kg.
Qashin tuurista	Kala tasho sharciyada gobolka, deegaanka ama qaranka si loo qubo.Tuuritaanka waa in loo sameeyaa si waafaqsan xeerarka rasmiga ah.Biyo, haddii loo baahdo walxaha nadiifinta.
kaydinta	N-Methyl-2-pyrrolidone waa hygroscopic (soo qaada qoyaanka) laakiin waxay ku xasilloon tahay xaaladaha caadiga ah.Waxay si xoog leh uga falcelin doontaa oksaydhiyeyaasha xooggan sida hydrogen peroxide, nitric acid, sulfuric acid, iwm. Badeecooyinka qudhunka ee aasaasiga ah waxay soo saaraan qiiqa carbon monoxide iyo nitrogen oxide.Soo-gaadhista xad-dhaafka ah ama daadinta waa in laga fogaadaa arrin wanaagsan.Shirkadda Kiimikada Lyondell waxay ku talinaysaa xidhashada galoofyada butyl marka la isticmaalayo N-Methyl-2-pyrrolidone.N-Methyl-2-pyrrolidone waa in lagu kaydiyaa nadiif, bir qafiif ah ama durbaanno alloy ah.Teflon®1 iyo Kalrez®1 ayaa la tusay inay yihiin qalab ku habboon.Fadlan dib u eeg MSDS ka hor inta aanad gacanta ku dhigin.
Sharaxaada	N-Methyl-2-pyrrolidone waa dareere aprotic ah oo leh codsiyo badan oo kala duwan: farsamaynta petrochemical, daahan dusha sare, midabada iyo midabada, xeryahooda nadiifinta warshadaha iyo guryaha, iyo qaababka beeraha iyo daawooyinka.Inta badan waa xanaaq, laakiin sidoo kale waxay keentay dhowr xaaladood oo dermatitis xiriir ah shirkad yar oo koronto ah.
Guryaha Kiimikada	N-Methyl-2-pyrrolidone waa dareere huruud ah oo aan midab lahayn ama iftiin leh oo leh ur amin.Waxay ku dhici kartaa tiro falcelin kiimikaad ah in kasta oo loo aqbalay dareere deggan.Waxay u adkaysataa hydrolysis ee xaaladaha dhexdhexaadka ah, laakiin aashitada xooggan ama daaweynta saldhigga ayaa keenta in giraanta u furto 4-methyl aminobutyric acid.N-Methyl-2-pyrrolidone waxaa lagu yarayn karaa 1-methyl pyrrolidine oo leh borohydride.Daawaynta maaddooyinka chlorinating waxay keenaysaa samaynta amide, dhex dhexaad ah oo lagu samayn karo beddelaad dheeraad ah, halka daawaynta amooniyamka ay dhaliso nitrate-ka.Olefins waxaa lagu dari karaa booska 3 iyadoo la daaweynayo marka hore oxalic esters, ka dibna aldehyes ku habboon (Hort iyo Anderson 1982).
Adeegsada	N-Methyl-2-pyrrolidone waa dareere polar ah oo loo isticmaalo kimistariga organic iyo kimistariga polymer.Codsiyada cabbirka weyn waxaa ka mid ah soo kabashada iyo nadiifinta acetylenes, olefins, iyo diolefins, nadiifinta gaaska, iyo soo saarista udugga ee feedstocks.N-Methyl-2-pyrrolidone waa dareere warshadeed oo isku dhafan.NMP hadda waxaa loo oggolaaday in lagu isticmaalo kaliya daawooyinka caafimaadka xoolaha.Go'aaminta hab-nololeedka iyo dheef-shiid kiimikaadka NMP ee jiirka ayaa gacan ka geysan doona fahamka sunta kiimikadan dibadda ah oo laga yaabo in ninku uu la kulmo xaddi sii kordhaya.
Adeegsada	Ku milmaya resins heerkul sarreeya;farsamaynta batroolka, ee warshadaha wax-soo-saarka microelectronics, midabada iyo midabaynta, xeryahooda nadiifinta warshadaha iyo guryaha;hababka beeraha iyo daawooyinka
Adeegsada	N-Methyl-2-pyrrolidone, waxay faa'iido u leedahay spectrophotometry, chromatography iyo ogaanshaha ICP-MS.
Qeexid	ChEBI: Xubin ka mid ah fasalka pyrrolidine-2-ones kaas oo ah pyrrolidin-2-mid kaas oo hydrogen ku xiran nitrogen lagu beddelay koox methyl ah.
Hababka wax soo saarka	N-Methyl-2-pyrrolidone waxaa soo saaray falcelinta buytrolactone ee methylamine (Hawley 1977).Nidaamyada kale waxaa ka mid ah diyaarinta hydrogenation of xalalka lab ama succinic acids leh methylamine (Hort iyo Anderson 1982).Soosaarayaasha kiimikadaan waxaa ka mid ah Lachat Chemical, Inc, Mequon, Wisconsin iyo GAF Corporation, Covert City, California.
Tixraaca(yada) Synthesis	Waraaqaha Tetrahedron, 24, b.1323, 1983kiiDOI: 10.1016/S0040-4039(00)81646-9
Sharaxaada Guud	N-Methyl-2-Pyrrolidone (NMP) waa dareere awood leh, aprotic ah oo leh dareere sare, iyo isbeddel hooseeya.Midabkan aan midab lahayn, karkarinta sare, dhibic sare iyo dareeraha uumiga oo hooseeya ayaa sidda ur khafiif ah oo amiinada u eg.NMP waxay leedahay xasillooni kiimiko iyo kulayl sare leh oo gebi ahaanba waa lagu khaldami karaa biyaha heerkul kasta.NMP waxay u adeegi kartaa isku-darka biyaha, alkolada, glycol ethers, ketones, iyo hydrocarbons caraf udgoon/koloriin leh.NMP labadaba waa dib loo warshadayn karaa iyada oo la nadiifiyo oo si diyaar ah loo nooleeyo.NMP lagama helo liiska Hawo Wasakhaysan (HAPs) ee 1990 Waxka bedelka Xeerka Hawada Nadiif ah.
Falcelinta Hawada & Biyaha	Biyo ku milmay.
Muuqaalka falcelinta	Aminkan waa saldhig kiimiko oo aad u khafiif ah.N-Methyl-2-pyrrolidone waxay u janjeertaa inay ka takhalusto asiidhka si ay u sameeyaan cusbo iyo biyo.Qadarka kulaylka ee ka soo baxa halkii mole amine ee dhex dhexaadnimada ayaa inta badan ka madax banaan xoogga aminiga sal ahaan.Amines waxa laga yaabaa in aanay ku haboonayn isocyanates, organics halogenated, peroxides, phenols (asiidh), epoxides, anhydrides, iyo halides acid.Haydarojiin gaasta guban kara waxaa soo saara amines oo ay weheliso walaxyo yareeya oo xooggan, sida hydrides.
Hazard	Maqaar daran iyo isha cuncun.Xadka qarxa - waa 2.2-12.2%.
Khatar Caafimaad	Neefsashada uumiga kulul wuxuu ka xanaajin karaa sanka iyo cunaha.Cuncunku wuxuu keenaa cuncun afka iyo caloosha.Indhaha la taabto waxay keentaa xanaaq.Xidhiidhka maqaarka ee soo noqnoqda iyo daba dheeraada waxa ay soo saartaa xanaaq fudud oo ku meel gaadh ah.
Khatarta Dabka	Khataraha Gaarka ah ee Alaabooyinka Gubashada: Sunta Nayroojiinku waxa ay ku samaysan karaan dab.
Daboolida iyo Qarxinta	Aan guban karin
Isticmaalka warshadaha	1) N-Methyl-2-pyrrolidone waxaa loo isticmaalaa sida dareeraha guud ee dipolar aprotic, deggan oo aan firfircoonayn; 2) si loo soo saaro hydrocarbons caraf udgoon ee saliidda saliidda; 3) ka saarida kaarboon oksijiinta ee abuurayaasha ammonia; 4) sida dareere loogu talagalay falcelinta polymerization iyo polymers; 5) sida rinji xariif ah; 6) oo loogu talagalay qaabaynta sunta cayayaanka (USEPA 1985). Isticmaalka kale ee aan warshadaha ahayn ee N-Methyl-2-pyrrolidone waxay ku salaysan yihiin sifooyinkeeda sida dareeraha kala-baxa ee ku habboon daraasaadka kiimikada iyo kiimikaad jirka (Langan iyo Salman 1987).Codsiyada dawooyinka waxay u isticmaalaan sifooyinka N-Methyl-2-pyrrolidone sidii kor u qaadida dhexgalka si dhakhso ah oo loogu kala wareejiyo walxaha maqaarka (Kydoniieus 1987; Barry and Bennett 1987; Akhter and Barry 1987).N-Methyl-2-pyrrolidone waxaa loo ansixiyay sidii dareere loogu talagalay codsiga slimicide ee alaabta baakadaha cuntada (USDA 1986).
La xidhiidh xasaasiyadaha	N-Methyl-2-pyrrolidone waa dareere aprotic ah oo leh codsiyo badan oo kala duwan: farsamaynta petrochemical, daahan dusha sare, midabada iyo midabada, xeryahooda nadiifinta warshadaha iyo guryaha, iyo qaababka beeraha iyo daawooyinka.Inta badan waa xanaaq, laakiin waxay keeni kartaa dermatitis xiriir daran taabashada dheer awgeed.
Xogta Badbaadada	Sunta marinka xididada.Sumo dhexdhexaad ah marka la nuugo iyo dariiqyada intraperitoneal.Wax yar oo sun ah taabashada maqaarka.Teratogen tijaabo ah.Saamaynta taranka ee tijaabada ah.Xogta is beddelka ayaa la sheegay.Guba marka uu la kulmo kulaylka, ololka furan, ama oksidizers xooggan.Si loola dagaallamo dabka, isticmaal xumbo, CO2, kiimiko qalalan.Marka la kululeeyo si uu u burburo waxa ay sii deysaa qiiq sun ah oo NOx ah.
Kansarka	Jiirka ayaa la kulmay uumiga N-Methyl-2-pyrrolidone ee 0, 0.04, ama 0.4 mg / L 6 h / maalin, 5 maalmood / usbuuca 2 sano.Wax saameyn ah oo nolosha-gaabinaya sunta ama kansarka laguma arag jiirka 2 sano ilaa 0.04 ama 0.4mg/L ee N-Methyl-2-pyrrolidone.Dariiqa maqaarka, koox ka mid ah jiirarka 32 ayaa helay qiyaasta bilawga ah ee 25mg ee N-Methyl-2-pyrrolidone oo ay ku xigto 2 toddobaad ka dib codsiyada buro dhiirrigeliyaha phorbol myristate acetate, saddex jeer toddobaadkii, in ka badan 25 toddobaad.Dimethylcarbamoyl chloride iyo dimethylbenzanthracene ayaa u adeegay sidii kontaroolo togan.Inkasta oo kooxda N-Methyl-2-pyrrolidone ay lahaayeen saddex burooyin oo maqaarka ah, jawaabtan looma tixgelinin mid muhiim ah marka la barbardhigo kuwa kantaroolka wanaagsan.
Jidka dheef-shiid kiimikaadka	Jiirka waxaa lagu maamulaa raadiyaha lagu sumadeeyay N-methyl-2-pyrrolidinone (NMP), iyo dariiqa ugu weyn ee jiirku ka soo baxo kaadida.Dheef-shiid kiimikaadka ugu weyn, oo ka dhigan 70-75% qiyaasta la maamulo, waa 4- (methylamino) butenoic acid.Alaabtaan aan dheregsanayn ayaa laga yaabaa in laga sameeyo ciribtirka biyaha, iyo koox hydroxyl ah ayaa laga yaabaa inay ku jiraan dheef-shiid kiimikaadka ka hor hydrolysis acid.
Dheef-shiid kiimikaad	Jiirka Sprague-Dawley ee labka ah ayaa la siiyay hal duritaan oo ah intraperitoneal (45 mg / kg) ee radiolabeled 1 -methyl-2-pyrrolidone.Heerarka Plasma ee shucaaca iyo isku dhafka ayaa la kormeeray muddo lix saacadood ah natiijaduna waxay soo jeedisay weji qaybin degdeg ah kaas oo ay ku xigto weji baabi'in tartiib ah.Qadarka ugu weyn ee calaamadda ayaa laga soo saaray kaadida 12 saacadood gudahood waxayna ka dhigan tahay ku dhawaad 75% qiyaasta la calaamadeeyay.24 saacadood ka dib qiyaasta, soo saarista isugeynta (kaadi) waxay ahayd qiyaastii 80% qiyaasta.Labada nooc ee giraanta-iyo methyl-labeled ayaa la isticmaalay, iyo sidoo kale labadaba [¹⁴C] - iyo [3H] -lagu calaamadeeyay l-methyl-2-pyrrolidone.Saamiyada hore ee calaamadeysan ayaa la joogteeyay 6-dii saacadood ee ugu horreysay ka dib qiyaasta.6 saacadood ka dib, beerka iyo mindhicirrada ayaa la ogaaday inay ku jiraan ururinta ugu badan ee shucaaca, qiyaastii 2-4% qiyaasta.Wax yar oo shucaac ah ayaa lagu arkay xaniinyaha ama hawada neefsanaysa.Waxqabadka sare ee chromatography dareeraha kaadida ayaa muujiyay joogitaanka hal weyn iyo laba dheef-shiid kiimikaad yar yar.Dheef-shiid kiimikaad weyn (70-75% qiyaasta shucaaca ee la maamulo) waxaa lagu falanqeeyay chromatography-mass spectrometry dareere ah iyo gaaska chromatography-mass spectrometry waxaana la soo jeediyay inuu noqdo 3- ama 5-hydroxy-l-methyl-2-pyrrolidone (Wells) 1987).
Hababka Sifaynta	Qalaji pyrrolidone adiga oo ka saaraya biyaha sida * benzene azeotrope.Si jajaban u kala fogee 10 torr iyada oo loo marayo tiir 100 cm ah oo ay ka buuxaan helices dhalo ah.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] Hydrochloride waxa uu leeyahay m 86-88o (ka EtOH ama Me2CO/EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.]