Wax soo wadaban
Tuubooyinka; CAS: 5625-37-6
ENOCYNS:1,4-piperazidethethane sulfonic acid;
1,4-piperrazidethethonic acid;
1,4-piperrazinethensuranfesulate; piperazine-n, n'-bis (2-enmaninsinic acid);
piperazine-n, n'-bis (2-enaninsisululic acid), cusbo sodium ah; tuubooyinka
Hantida kiimikada ee tuubooyinka
● Imaanshaha / Midabka: Budada Caddaanka cad
● dhibic dhalaal:> 300 ° C (iftiin.)
● Index nooleeya): 1.6300 (qiyaasta)
PKA: 6.8 (25 ℃)
Psa PSA: 131.98000
● cufnaanta: 1.505 g / cm3
● LOGP: 0.41700
● Kaydinta ku meel-gaarka ah ee kaydhka rt.
SO SO SOLUBLELE.:0.1 MEEh: 0.25 g / ml, cad, midab la'aan
Wadahada biyaha.
● Xlogp3: -6.7
● Ku tabaruca degganaanshaha deganaanshaha hydrogen-ka tirinta: 2
● Aqbalida debaajiga Hydrogen debaaji: 8
● Tirada debaajiga la wareegi karo: 6
● sax ah tirada saxda ah: 302.06062865
● Tirinta culus ee atomka: 18
Isku-duwaha: 397
Daahir / tayo
99% * Xogta ka soo baxa iibiyaasha cayriin
1,4-piperrazinebis (Ethanasullumikacid) 99% * Xogta ka soo bixiyeyaasha soo iibsadaha
Macluumaadka SAFT
● Sawirada (yada):
Xi
● Koodhadhka Hazard: XI
● Hadalada: 36/37/38
● Hadafyada badbaadada: 22-24 / 25-37 / 39-26
Waxtar leh
Fasalada kiimikada:Isticmaalayaasha kale -> Buffers bayoolojiyada
Dhoola cadeynta canonical:C1cn (ccn1ccs (= o) (= o) o) ccs (= o) (= o) o
Adeegsiga:Piperazine-n, n'-bis- (2-Eninnansulphonic acid) Ultra -pure> 99.5%) waa kiimiko muhiim u ah dhammaan noocyada beeraha ee muhiimka ah. 1,4-piperazidethethethesulfonic acid, piperazine-n, n'-enano-bis- (tuubooyinka Ethanasiclufonic acid) (tuubbooyinka) ayaa sidoo kale ah kuwa ugu habboon ee tijaabada bayoolojiga ah illaa PK2 ee tuubooyinka ay tahay 6.8 at 20 digriis Celsius. Wakiilka wax lagu dhejiyo ee PKA u dhow Ph.pipes [Piperazine-n, N'-Mesul (ACTANESulSulFonic acid)] waxaa badanaa loo isticmaalaa wakiilka wax lagu dhejiyo ee ku yaal bayoolajiga. Waa wax loo yaqaan 'EvaninfloNic acid' oo ay soo saareen wanaagsan et al. 1960-meeyadii. Tuubooyinka waxay leeyihiin PKA meel u dhow PH-ga Phe Phe Phe kaas oo ka dhigaya mid waxtar u leh shaqada dhaqanka ee qoyska. Waxaa loo diiwaangeliyay in la yareeyo khasaaraha lipid marka la dhiso Glufering Glutaraldehydestisiologystiologs ee geedka iyo xayawaannada, cusbada, cusbada dhiigga; Tuubooyinka mipotasium cusbo; Tuubooyinka milix. Tuubooyinka, cusbada sodium. Dhaqaalaha waxaa lagu diyaarin karaa iyadoo lagu daro xalka saldhigga si loo tuuro aashito bilaash ah, oo lagu qaso salkan ku habboon, ama milixyada milixda ee milixda iyo milixyada dib-u-dhigga, oo ku habboon ph. Tuubbada, waxaa loo isticmaalaa wakiilka wax lagu keydiyo ee bayoolajiga. Tuubooyinka waxay leeyihiin PKA (6.76 25 ° C) ee u dhow Phe Phe Phe Phe Phe Phe oo ka dhigaya mid waxtar u leh shaqada dhaqanka. Borotokool ayaa lagu soo sheegay in la adeegsanayo tuubooyinka loogu talagalay kala-sooca RNA-ga GellyLylens ee Gells, khariidaynta nuclase S1 ee RNA, iyo is-xakamaynta digaaga. Tuubbooyinka waxaa loo isticmaalay sidii wax lagu dhejiyo Tuubbooyinka waxaa lagula taliyaa in loo isticmaalo wax lagu dhejiyo ee wax lagu dhejiyo ee barashada cudurka vitro-ka Tuubbooyinka waxaa loo adeegsaday dhaqanka unugyada ee loogu talagalay codsiyadan oo kale ah in injineernimada borotiinka xuubka uurka leh ee Escherichia Coli.
Hordhac faahfaahsan
Tuubooyinka bilaashka ah, oo sidoo kale loo yaqaan 1,4-piperazidethethethesulfonic acid, waa waxtarka wanaagsan ee ku habboon lahaanshaha PKA oo la mid ah PH-yada jirka ee caadiga ah. Sidaas oo ay tahay, tuubooyinku aashita oo bilaash ah ayaa had iyo jeer loo isticmaalaa sidii wax lagu dhejiyo cilmi-baarista biochemical. Tuubbooyinka ayaa ka maqan awooda ay ku dhisi karaan cashuuraha weyn ee ionga birta badankood waxaana lagula talinayaa in loo isticmaalo sidii isku-duwaha aan isku-xirnayn ee xalka ionda birta ah. Tuubooyinka waxay leeyihiin codsiyo kala duwan oo kala duwan waxaana badanaa loo adeegsadaa warbaahinta dhaqaalaha, ee cellotein crystallis, sida loo yaqaan 'profeilin crystallis', oo ah xayiraadda kombiyuutarka ee Gel Encerophoresis, iyo sidii loo sifeynin isoelecticric diiradda iyo koromada. Buffer-kani wuxuu awood u leeyahay sameynta xag-jirnimada oo sidaas darteed kuma haboona jawaab celinta 'Resox'. Waxay ku habboon tahay in lagu isticmaalo aashitada bisilchinchinic acid (BCA) ee Assay. Xoolaha tuubooyinka ayaa kordha marka aashitada bilaashka ah loo rogo cusbada sodium-ka lagu daro iyadoo lagu daro xalka saldhiga ee tuubooyinka aashitada oo bilaash ah oo ay ku dhegan yihiin ph
Tuubooyinka waxay xubin ka tahay taxanaha Attersulfonfonic acid ee aashitada, marka hore waxay soo bandhigtay si wanaagsan et al. Isbeddelka ugu yar ee heerkulka, heerka mimiriga ee heerkulka, kafaalanka ugu yar ee ka jira tirada muuqaalka ah ee muuqaalka ah ama uv scripral iyo si fudud ayaa loo saadaaliyaa. Maaddaama PKA ay tahay 37 ° C uu u dhow yahay jir ahaaneed, tuubooyinku waxay leeyihiin codsiyo ku saabsan shaqada dhaqanka ee unugyada.
Hordhac faahfaahsan
Tuubbooyinka, oo sidoo kale loo yaqaan piperazine-n, n'-enataninflonic acid), waa xayndaab inta badan loo isticmaalo cilmibaadhista bayoolojiga iyo cilmi baarista bayoolaji. Waa xarun zwitterteronic ah oo ka caawisa in la ilaaliyo phe deganaansho ee xalka aqueolow.
Mid ka mid ah codsiyada aasaasiga ah ee tuubooyinka tuubooyinka ah ayaa ku jira bayoolajiga molikalista iyo bayoolajiga, halkaas oo loo adeegsado wax u beddelaya diyaarinta diyaarinta iyo keydinta sanbabka bayoolojiga. Tuubooyinka waxay leeyihiin qiime-ciyaareed oo ku dhawaad 7.46, taas oo ka dhigaysa mid ku habboon dayactirka tirada PH oo ah 6.7 ilaa 7.9 heerkulka jir ahaaneed (qiyaastii 37 darajo Celsius).
Tuubbooyinka ayaa si gaar ah waxtar ugu leh dayactirka xasilloonida sadarka ah inta lagu gudajiro howlaha sida nadiifinta borotiinka, enzyme assys, iyo gelrophoresis. Waxay kaa caawineysaa in la yareeyo isbeddelada PH ee suurta galka ah oo saameyn ku yeelan kara qaab-dhismeedka iyo shaqada borotiinnada iyo enzymes-ka.
Codsi kale oo tuubooyin ah ayaa ku jira cilmi baarista dhaqanka ee unugyada. Waxaa caadi ahaan loo istcimaalaa sidii wax lagu dhejiyo oo loogu talagalay warbaahinta dhaqanka unugyada. Tuubooyinku waxay ka caawisaa sidii loo ilaalin lahaa PH oo joogto ah dhexdhexaadka kobaca, kaasoo muhiim u ah koritaanka iyo suuragalnimada unugyada. Waxay kaloo bixisaa jawi deggan oo loogu talagalay barashada barashada geedi socodka gacanta iyo sameynta tijaabooyin.
Tuubbooyinka waxaa sidoo kale loo adeegsadaa farsamooyin kala duwan oo falanqeeya, sida dareeraha dareeraha iyo isku-darka koronto-qaadista. Awooda wax soo dhigga iyo xasilloonida PH waxay ka dhigtaa mid ku habboon in lagu isticmaalo farsamooyinkan, halkaasoo xakamaynta PH ee saxda ah ay muhiim u tahay natiijooyinka saxda ah.
Intaa waxaa sii dheer, tuubooyinka ayaa laga helay codsiyo ku saabsan sameynta daweynta iyo nidaamyada dhalmada. Waxaa loo isticmaali karaa sidii wax lagu dhejiyo oo ah qaab-dhismeedka dawooyinka si loo saadaaliyo xasilloonida daroogada iyo kor u qaadista nuugista daroogada.
Guud ahaan, tuubooyinka ayaa ah wakiil xayeysiin ah oo iskuxiran oo leh codsiyo fara badan oo ku saabsan cilmi baarista bayoolojiga iyo cilmi baarista bayoolajiga ah, dhaqanka unugyada, farsamooyinka falanqaynta, iyo qaababka dawooyinka. Awoodda ay u leedahay in la joogteeyo xasilloonida pH waxay ka dhigeysaa aalad qiimo u leh meelaha kala duwan ee cilmiga ah.
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